Injection Molding Technics for Poly (lactic acid)

Poly-L-lactic acid: consultation on the injection techniques.

OBJECTIVES When poly-L-lactic acid (PLLA) was first introduced (marketed as New-Fill), incorrect injection technique was largely responsible for the manifestation of device-related adverse events in the form of subcutaneous papules and areas of induration. Now marketed as Sculptra, widespread clinical experience with injectable PLLA has resulted in a wealth of information on product reconstitut...

Late-onset granuloma formation after poly-l-lactic acid injection

INTRODUCTION Poly-L-lactic acid (Sculptra, Sanofi Aventis, Bridgewater, NJ) is a gel polymer made of poly-Llactic acid microspheres and water suspended in a mannitol and carboxymethyl cellulose suspension. This injectable tissue filler has been used for correction of lipoatrophy in HIV patients as well as for cosmetic purposes since its US Food and Drug Administration approval in 2004. The mech...

Poly(lactic acid) (PLA) Nanofibers for Bone Tissue Engineering

Safety evaluation of poly(lactic-co-glycolic acid)/poly(lactic-acid) microspheres through intravitreal injection in rabbits

Poly(lactic-co-glycolic acid) (PLGA) and/or poly(lactic-acid) (PLA) microspheres are important drug delivery systems. This study investigated eye biocompatibility and safety of PLGA/PLA microspheres through intravitreal injection in rabbits. Normal New Zealand rabbits were randomly selected and received intravitreal administration of different doses (low, medium, or high) of PLGA/PLA microspher...

Functional Properties of Biodegradable Nanocomposites from Poly Lactic Acid (PLA)

Nanocomposite composed of organoclay(Cloisite 20A-C20A) and Poly lactic acid (PLA) was prepared by solvent casting method. Physical, mechanical, thermal, barrier and microstructure properties of the composite were studied. X-Ray diffraction (XRD) patterns and scannin...